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Target intelligence / Profile preview
Dopamine receptor D2S (D2S)
- Target
- D2S
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Dopamine receptor D2S (short isoform) is one of two main splice variants of the dopamine D2 receptor, a member of the G protein-coupled receptor (GPCR) family. The D2S isoform is generated by alternative splicing and differs from the long form (D2L) by lacking a 29-amino acid segment in the third intracellular loop. It functions primarily as an inhibitory autoreceptor on dopaminergic neurons; it regulates synthesis/release via Gi/o-mediated pathways that decrease cAMP production and neuronal excitability.
- Other names
- D2 short isoformDRD2SDopamine D2 autoreceptor
02
Mechanism of action
Gi/o protein activation, inhibition of adenylyl cyclase, reduction of cAMP levels, inhibition of voltage-gated calcium channels, activation of G-protein inwardly rectifying potassium channels (GIRK)
03
Biological functions
Signal transductionAutoinhibition of dopamine releaseRegulation of dopamine synthesisRegulation of dopamine reuptake
04
Disease associations
SchizophreniaParkinson's diseaseAddiction
05
Safety considerations
Extrapyramidal symptoms (EPS)Tardive dyskinesiaNeuroleptic malignant syndrome
06
Interacting drugs
Antipsychotics
2 more in the full profile.
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