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Target intelligence / Profile preview
Dopamine Receptor D4 (DRD4)
- Target
- DRD4
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Dopamine receptor D4 (DRD4) is a G protein-coupled receptor that plays a role in neuronal signaling in the mesolimbic system. It is involved in emotion and complex behavior. DRD4 contains a polymorphic region with variable numbers of repeats, leading to functional differences among individuals. It is implicated in several neuropsychiatric disorders and is a target for antipsychotics and other drugs.
02
Mechanism of action
Inhibition of adenylate cyclase via Gi/o protein coupling
03
Biological functions
Signal transductionModulation of cognitionAttentionLearningMotor controlEmotionsReward processing
04
Disease associations
SchizophreniaBipolar disorderAttention-deficit hyperactivity disorder (ADHD)Addictive behaviors/substance use disordersParkinson’s diseaseEating disordersRestless legs syndromeBorderline personality disorder
05
Safety considerations
Potential for off-target effects due to structural similarity with other dopamine receptorsVariations in response to drugs based on VNTR polymorphism
06
Interacting drugs
Clozapine
5 more in the full profile.
07
Biomarkers
VNTR polymorphism within exon 3 (number of repeats)Allelic variants of DRD4
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