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Target intelligence / Profile preview
Dopamine Receptor D5 (DRD5)
- Target
- DRD5
- Molecular classification
- G protein-coupled receptor, GPCR, Dopamine Receptor, D1-like receptor, Type I Dopamine Receptor, Class A GPCR
01
Overview
The dopamine receptor D5 (DRD5) is a G protein-coupled receptor that belongs to the D1-like dopamine receptor family. It is primarily expressed in the central nervous system and is involved in various functions, including working memory, reward processing, and motor control. DRD5 has a high affinity for dopamine and stimulates adenylyl cyclase activity, leading to increased cAMP production. It exhibits high constitutive activity and plays a role in BDNF induction and Akt phosphorylation.
- Other names
- D1B ReceptorDRD(DA) ReceptorD(1B) Receptor
02
Mechanism of action
Agonist binding leads to activation of adenylyl cyclase via Gαs/olf proteins, increasing intracellular cAMP levels.
03
Biological functions
Signal transductionAdenylyl cyclase activationcAMP productionWorking memory modulationBDNF inductionAkt phosphorylationRegulation of voluntary movementReward processingMotivationSleep regulationFeeding behaviorAppetite controlAttentionCognitionExecutive functionOlfactionSensory processing
04
Disease associations
Neurological disordersCognitive disordersPsychiatric disordersAddiction
05
Safety considerations
Potential for off-target effects due to similarity with D1 receptorSide effects related to dopaminergic system modulation (e.g., motor dysfunction, psychosis)
06
Interacting drugs
Dopamine
1 more in the full profile.
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