Dopamine receptor D5 pseudogene 2 (DRD5P2)

Dopamine receptor D5 pseudogene 2 (DRD5P2) is a pseudogene closely related to the functional dopamine receptor D5 (DRD5). While the authentic DRD5 gene encodes a protein that is a G protein-coupled receptor (GPCR) involved in dopamine signaling, DRD5P2 is a non-functional DNA segment that arose by gene duplication and sequence divergence[1][3][7][8]. It shares high sequence similarity (over 95%) with the functional DRD5 gene, but contains insertions, deletions, and multiple in-frame stop codons, which prevent it from producing a functional protein[1][3][5][7]. Transcription of DRD5P2 can occur, but the RNA product is not translated into a receptor protein, and thus DRD5P2 has no established biological function, disease association, or pharmacologic relevance[1][3][7]. It is not considered a therapeutic target and has no known role in drug interaction, mechanism of action, or as a disease biomarker. Key clarification: - DRD5P2 is a pseudogene and not a true protein-coding gene, receptor, or drug target. - Some databases may list it alongside the functional DRD5 gene, but only DRD5 (not DRD5P2) encodes the G protein-coupled dopamine receptor implicated in drug response and neurobiology[1][3][7][8]. - If you are interested in the actual dopamine D5 receptor, refer to "Dopamine receptor D5" (DRD5). Summary: Dopamine receptor D5 pseudogene 2 (DRD5P2) is a pseudogene related to, but functionally distinct from, the true dopamine receptor D5. DRD5P2 does not encode a functional protein and is not a therapeutic or pharmacologic target[1][3][7][8].

Other names

DRD5P2dopamine receptor D5 pseudogene 2dopamine receptor D5 pseudogeneLOC101060524