Dopamine receptor D5 subtype (D5R)

Dopamine receptor D5 subtype (D5R) is a G protein-coupled receptor of the D1-like dopamine receptor family, encoded by the DRD5 gene in humans[1][2]. D5R has roughly 10-fold higher affinity for dopamine compared to the D1 receptor[1]. Upon activation, D5R stimulates adenylyl cyclase, leading to increased intracellular cAMP through Gαs/olf protein coupling[1][2]. D5R is highly expressed in cortical brain regions and plays a critical role in regulating learning and memory, neuronal oscillatory activity, and cognitive processes[4]. Dysfunction or altered signaling through D5R is implicated in cognitive impairment and potentially other neuropsychiatric conditions[4]. Pharmacological targeting of D5R may modulate brain-derived neurotrophic factor and protein kinase B signaling[1][4]. Few ligands distinguish D5R reliably from D1R due to their close homology, making highly selective drugs difficult to develop[1][4].

Other names

Dopamine D5 receptorDRD5 (gene name)D1BR

Agonists mimic dopamine action, activating the receptor, promoting cAMP synthesis via Gαs/olf signaling. Antagonists/inverse agonists block receptor activation or induce opposite signaling effects.