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Target intelligence / Profile preview
Dopamine Receptor Type 2 (DRD2)
- Target
- DRD2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The dopamine receptor D2 (D2R) is a G protein-coupled receptor (GPCR) encoded by the DRD2 gene. It plays a crucial role in regulating dopamine neurotransmission, influencing motor control, motivation, reward processing, and mood. It exists in two main isoforms, a long (D2L) postsynaptic form and a short (D2S) presynaptic autoreceptor form. D2R is a primary target for antipsychotic drugs and is implicated in several neurological and psychiatric disorders, including Parkinson's disease and addiction. The receptor also forms heteromers with other GPCRs, modulating its pharmacology and functional output.
- Other names
- D2 receptorD₂ receptorDopamine D2 receptor
02
Mechanism of action
Antagonism at D2 receptor
03
Biological functions
Signal transductionAutoregulatory feedback on DA neuronsPostsynaptic inhibitionRegulation of dopamine synthesis, release, and reuptake
04
Disease associations
SchizophreniaParkinson’s diseaseAddictionMovement disordersMood disorders
05
Interacting drugs
Antipsychotic drugs
1 more in the full profile.
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