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Dopamine Plasma Membrane Transport Protein (DAT)
- Target
- DAT
- Molecular classification
- Transporter
01
Overview
The dopamine plasma membrane transport protein, commonly known as the dopamine transporter (DAT), is a membrane-spanning protein primarily responsible for the reuptake of dopamine from the synaptic cleft back into presynaptic neurons. This process terminates dopaminergic signaling and regulates extracellular dopamine levels.
- Other names
- Dopamine transporterSLC6A3DAT1
02
Mechanism of action
Inhibition of dopamine reuptake, reverse transport of dopamine
03
Biological functions
Neurotransmitter reuptakeRegulation of extracellular dopamine levelsTermination of dopaminergic signaling
04
Disease associations
Attention deficit hyperactivity disorder (ADHD)Bipolar disorderClinical depressionAlcoholism
05
Interacting drugs
Amphetamines
1 more in the full profile.
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