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Dopamine Transporter Protein (DAT)
- Target
- DAT
- Molecular classification
- Transporter, Membrane protein
01
Overview
The dopamine transporter (DAT), encoded by the SLC6A3 gene, is an integral membrane protein responsible for clearing dopamine from the synaptic cleft by transporting it back into presynaptic neurons. This reuptake process regulates extracellular dopamine levels, which are critical for various aspects of cognition, including reward processing. DAT function is implicated in several neuropsychiatric disorders and is the direct target of psychostimulants like cocaine and amphetamines.
- Other names
- Sodium-dependent dopamine transporterSLC6A3DAT1
02
Mechanism of action
Cocaine blocks reuptake of dopamine by DAT; amphetamines reverse the transport direction of DAT, leading to increased synaptic dopamine concentrations.
03
Biological functions
Neurotransmitter reuptakeRegulation of synaptic dopamine levelsDopamine:sodium symporterHeterocyclic compound binding
04
Disease associations
Attention deficit hyperactivity disorderBipolar disorderClinical depressionEating disordersSubstance use disorders
05
Safety considerations
Potential for drug abuse and dependence due to modulation of dopamine levels by targeting DAT.
06
Interacting drugs
Cocaine
1 more in the full profile.
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