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Target intelligence / Profile preview
Dopamine Uptake Inhibitor (DRI)
- Target
- DRI
- Molecular classification
- Reuptake Inhibitor
01
Overview
A dopamine uptake inhibitor is a compound that blocks the reabsorption (reuptake) of the neurotransmitter dopamine from the synaptic cleft, increasing dopamine levels and dopaminergic neurotransmission. The primary target is the dopamine transporter (DAT). These agents are used therapeutically for conditions like ADHD, narcolepsy and depression, but also carry a risk of abuse and addiction due to their effects on brain reward pathways.
- Other names
- Dopamine Reuptake InhibitorDAT Inhibitor
02
Mechanism of action
Blocks the reuptake of dopamine by inhibiting the dopamine transporter (DAT)
03
Biological functions
Modulation of dopamine neurotransmissionIncrease of extracellular dopamine levels
04
Disease associations
ADHDNarcolepsyDepressionObesityBinge Eating DisorderAddiction
05
Safety considerations
Abuse potentialAddictionCardiovascular effectsPsychiatric side effects
06
Interacting drugs
Bupropion
2 more in the full profile.
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