Dopaminergic nervous system

"Dopaminergic nervous system" is not a canonical name for a single molecule or receptor; rather, it refers to the entire system of neurons and receptors that utilize dopamine as a neurotransmitter. Typically, therapeutic targets in this system are individual dopamine receptors (such as D1, D2, D3, D4, D5) or dopamine transporter proteins, not the whole system as a single target[1][3]. The dopaminergic nervous system encompasses the network of neurons, receptors, and molecular pathways that utilize dopamine for neurotransmission. It is essential for motor control, reward processing, cognition, and mood regulation. Key molecular targets within this system include various dopamine receptors (D1–D5, all G protein-coupled receptors), dopamine transporter (DAT), and enzymes involved in dopamine synthesis and metabolism. Dysregulation of this system is implicated in Parkinson's disease, schizophrenia, mood disorders, and addiction[1][3][4]. As an umbrella term, it does not correspond to a single canonical molecular target. For structured data, specific entities such as "Dopamine D2 receptor" should be used instead, making this entry incorrect for a canonical single-molecule target in pharmacology.

Other names

Dopaminergic systemCentral dopaminergic pathwayDopamine system

Agonism/antagonism of dopamine receptors[3]; Modulation of dopamine release or reuptake[3]