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Target intelligence / Profile preview
Dorsal root ganglia homeobox protein (DRGX)
- Target
- DRGX
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
Dorsal root ganglia homeobox protein (DRGX) is a transcription factor that binds sequence-specific double-stranded DNA and regulates gene expression essential for the development and correct projection of nociceptive sensory neurons in the dorsal horn of the spinal cord, contributing to normal pain perception and sensory nervous system development. It is not currently considered a therapeutic target, with no known direct drug interactions or use as a biomarker. Mutations or deletions involving DRGX may be associated with neurodevelopmental and myasthenic syndromes.
- Other names
- DRGXPRRXL1DRG11Paired-related homeobox protein-like 1paired-like homeodomain transcription factor DRG11paired-related homeobox-like 1
02
Biological functions
Transcription regulationNervous system developmentSensory neuron differentiationDetection of temperature stimulusSensory perception of mechanical stimulus
03
Disease associations
Chromosome 16p12.2-p11.2 deletion syndromeMyasthenic syndrome congenital, 6, presynaptic
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