Dorsolateral prefrontal cortex (DLPFC)

The dorsolateral prefrontal cortex (DLPFC) is a functional region of the prefrontal cortex located in the middle frontal gyrus, primarily corresponding to Brodmann areas 9 and 46. It plays a central role in executive functions such as working memory, cognitive flexibility, planning, inhibition, and abstract reasoning. The DLPFC is not an individual molecule or receptor but rather a brain region composed of neural circuits that integrate sensory input with short-term memory and motor signaling. It has extensive connections with other cortical and subcortical regions including the orbitofrontal cortex, thalamus, basal ganglia (especially dorsal caudate nucleus), hippocampus, and association areas across temporal, parietal, and occipital lobes. Dysfunction or lesions in this area are associated with deficits in executive function tasks such as organization of behavior and adaptation to rule changes[1][2][3].\n\nNote on correctness:\nThe "dorsolateral prefrontal cortex" refers to a brain region—not a discrete molecular target like a receptor or enzyme—so it does not fit standard drug target classifications such as "receptor," "enzyme," etc.[1] This makes it an incorrect entry for lists specifically requiring molecular targets.

Other names

DLPFCDL-PFCdorsolateral PFC