Dorsolateral prefrontal cortex neuron (DLPFC neuron)

The **dorsolateral prefrontal cortex neurons** are neuronal cells located within the dorsolateral prefrontal cortex (DLPFC), a functionally defined region of the primate frontal lobe. The DLPFC is involved in higher-order cognitive processes including working memory, cognitive flexibility, planning, inhibition, abstract reasoning, and top-down emotional regulation. It is also implicated in motor planning and organization. The DLPFC contains diverse neuronal subtypes—excitatory pyramidal neurons and various classes of inhibitory interneurons—with complex connectivity to other cortical and subcortical regions such as the thalamus, basal ganglia, hippocampus, parietal lobe, temporal lobe, cingulate gyrus, premotor areas, and cerebellum[3][4]. Recent molecular studies have revealed both conserved cell types across primates as well as human-specific specializations at the transcriptomic level. For example, certain genes associated with neuropsychiatric risk show unique expression patterns in human or primate-specific neuronal subtypes within this region[4][6]. Dysfunction or altered molecular networks among these neurons have been linked to psychiatric conditions like schizophrenia—particularly involving immune response pathways—and may underlie negative symptoms or cognitive deficits observed in these diseases[2]. While "Dorsolateral prefrontal cortex neuron" describes an important population for neuroscience research into cognition and disease mechanisms—and is sometimes targeted indirectly by neuromodulation therapies—it does **not** refer to a canonical druggable target such as a receptor or enzyme. **Note:** This entry is considered *incorrect* for structured drug-target databases because it refers to an anatomical/functional population rather than a specific molecule/protein that can be directly targeted by drugs. If you require information on specific receptors or proteins expressed by these neurons (such as dopamine receptors), those should be listed individually using their canonical names.

Other names

DLPFC neuronNeuron of the dorsolateral prefrontal cortexdlPFC neuron