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Double C2-like domain-containing protein alpha (DOC2A)
- Target
- DOC2A
- Molecular classification
- Other (tandem C2-domain protein, calcium sensor)
01
Overview
Double C2-like domain-containing protein alpha (DOC2A) is a calcium-sensing, tandem C2-domain protein that binds both calcium and phospholipids, likely regulating fusion of vesicles with membranes and facilitating calcium-dependent neurotransmitter release in neuronal cells. DOC2A is predominantly expressed in the brain and may also regulate secretory lysosome exocytosis in mast cells. It interacts with proteins such as UNC13A and UNC13B, and its dysfunction is associated with neurological phenotypes—particularly neurodevelopmental disorders related to chromosome 16p11.2. While essential in synaptic vesicle exocytosis, it is not recognized as a direct therapeutic target, and there are no clinically relevant drugs known to target DOC2A directly.
- Other names
- Double C2 domain alphaDOC2ADoc2Doc2-alphadouble C2-like domains, alphadoc2-alphadouble C2 protein alpha
02
Biological functions
Calcium-dependent neurotransmitter releaseCalcium ion bindingSyntaxin bindingRegulation of fusion of vesicles with membranesSecretory lysosome exocytosis in mast cells
03
Disease associations
Neurodevelopmental disorders (e.g., Chromosome 16p11.2 duplication syndrome)Seizures
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