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Target intelligence / Profile preview
Double C2-like domain-containing protein beta (DOC2B)
- Target
- DOC2B
- Molecular classification
- Other, Calcium sensor protein, Vesicle trafficking protein
01
Overview
Double C2-like domain-containing protein beta (DOC2B) is a tandem C2-domain calcium sensor protein involved in calcium-dependent vesicle trafficking and exocytosis. It is expressed in neuronal tissues, where it regulates spontaneous and asynchronous neurotransmitter release, as well as in endocrine cells such as pancreatic β-cells, where it is critical for glucose-stimulated insulin secretion. DOC2B acts by binding calcium and phospholipids, facilitating SNARE-dependent membrane fusion. Structurally, its C2B domain is the primary high-affinity calcium sensor, while the C2A domain assists in membrane interaction. Decreased DOC2B expression is associated with impaired insulin release, and its secretion in extracellular vesicles may reflect β-cell functional status. DOC2B is not a known pharmacological target, but it plays essential roles in neuroendocrine secretion physiology
- Other names
- DOC2BDOC2BLDoc2-betadouble C2-like domain-containing protein betadoc2-beta
02
Biological functions
Calcium-dependent phospholipid bindingRegulation of exocytosisSynaptic vesicle release (neurotransmitter release)Insulin secretion in pancreatic β-cellsVesicle priming
03
Disease associations
Diabetes (type 1 diabetes, impaired insulin secretion)Neuroendocrine dysfunctionOther (no strong evidence for a direct role in cancer, neurodegeneration, or cardiovascular disease)
04
Biomarkers
Reduced DOC2B levels in β-cells and plasma/EVs may serve as a disease biomarker for β-cell dysfunction or progression in type 1 diabetes
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