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Double Homeobox 4 (None)

Target: None
Molecular classification: Transcription factor

Overview

Double homeobox 4 (DUX4) is a transcription factor that regulates gene expression during early embryonic development. In healthy tissue, DUX4 is normally silenced but is aberrantly expressed in facioscapulohumeral muscular dystrophy (FSHD), leading to muscle wasting. Due to its role in transcriptional regulation and disease, DUX4 is considered a therapeutic target. Potential therapeutic interventions involve modulating its expression or inhibiting its activity.

Other names: DUX4Double homeobox protein 10Double homeobox protein 14/10Double homeobox protein-like

Mechanism of action

Modulation of DUX4 expression or activity

Biological functions

Gene transcription regulationRegulation during early embryogenesis

Disease associations

Facioscapulohumeral Muscular DystrophySoft Tissue Sarcoma

Safety considerations

Potential for off-target effects due to the transcription factor activityUnintended consequences of modulating developmental pathways

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