Double homeobox 4 like 22 (DUX4L22)

Double homeobox 4 like 22 (DUX4L22) is classified as a pseudogene, meaning it is a DNA sequence related to the protein-coding DUX4 gene but does not produce a functional protein.[2] DUX4L22 resides in the genome and may share sequence similarity to DUX4, a transcription factor involved in embryonic development and associated with diseases such as facioscapulohumeral muscular dystrophy (FSHD), cancer, and certain leukemias[1]. However, DUX4L22 itself lacks demonstrated biological function, protein expression, or direct mechanistic disease involvement, and is not considered a therapeutic target or biomarker. Its inclusion in gene and disease association databases is based on genomic proximity and sequence similarity rather than functional evidence[2][4]. Important context: - The canonical, active molecule in this family is **Double homeobox 4 (DUX4)**, which is a sequence-specific transcription factor with key roles in development and disease pathology[1][3][5]. - DUX4L22 is **not** a known receptor, enzyme, transporter, or transcription factor; it is **not a therapeutic target**[2][4]. - DUX4L22 is often listed only because of sequence similarity to DUX4, but there is no evidence for any functional protein, disease role, interaction with drugs, or use in biomarkers. Summary of accuracy: - DUX4L22 is a pseudogene and likely not a direct functional molecule. - If you intended the canonical DUX4 protein, use “Double homeobox 4 (DUX4)” instead, which is a transcription factor and a clinically relevant therapeutic target[1][3][5]. - The query is likely **incorrect** or misleading in terms of functional biology and therapeutic targeting.

Other names

DUX4L22Double homeobox 4 like 22 (Pseudogene)