Double homeobox 4 like 7 (DUX4L7)

Double homeobox 4 like 7 (DUX4L7) is a human pseudogene found within the D4Z4 repeat array on chromosome 4q. While the DUX4 gene within this locus encodes a double homeobox transcription factor involved in muscle development and facioscapulohumeral muscular dystrophy (FSHD)[1][2][4], DUX4L7 itself is categorized as a pseudogene, with no documented transcription or function[4]. There is no evidence that DUX4L7 produces a functional protein or serves as a therapeutic target; its presence may be relevant chiefly for structural genomic studies. Reports of involvement in disease reflect its genomic location rather than direct molecular activity. DUX4L7 is not considered an active protein, nor a receptor/enzyme/transcription factor. Evidence for transcriptional regulation or disease involvement references the functional DUX4 gene, not the DUX4L7 pseudogene[4][2]. If structured information about a functional molecule was intended, the query should refer to Double homeobox 4 (DUX4) rather than DUX4L7[1][2].

Other names

Double homeobox protein 4-like protein 7DUX4L7double homeobox protein 4-like protein 7