Double homeobox 4 like 8 (DUX4L8)

Double homeobox 4 like 8 (DUX4L8) is a human gene annotated as a pseudogene and described by the HUGO Gene Nomenclature Committee (HGNC). It does not encode a functional protein and has no documented disease association, biological function, or interaction with therapeutics. Its status and locus type are formally "pseudogene," meaning it is a non-functional genomic DNA sequence related to a gene with a biological role, most closely resembling the DUX4 gene which encodes a double homeobox protein involved in transcription regulation and disease[1][3][5]. DUX4L8 should not be confused with DUX4, which is a validated therapeutic and research target[2][4]. Note: If you are seeking information about the double homeobox protein implicated in therapy or disease, the proper target is Double homeobox 4 (DUX4), not DUX4L8. DUX4 is a transcription factor involved in muscular dystrophy and leukemia[2][4]. DUX4L8 is just a pseudogene and does not encode a protein, therefore not suitable for therapeutic targeting, biomarker analysis, or pharmacological modulation[1][3][5].

Other names

DUX4L8double homeobox 4 like 8DUX2double homeobox 2double homeobox, 4-likeputative double homeobox protein 2