Double homeobox A pseudogene 8 (DUXAP8)

Double homeobox A pseudogene 8 (DUXAP8) is a pseudogene-derived long noncoding RNA (lncRNA) located on chromosome 22q11, with a transcript length of 2107 bp[3]. DUXAP8 is transcribed as an lncRNA, functioning primarily in the cytoplasm and nucleus, where it serves as an epigenetic regulator and competing endogenous RNA (ceRNA)[2][3][4]. DUXAP8 is overexpressed in multiple cancer types, where it promotes cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and chemoresistance, primarily through mechanisms such as:\n- Sequestration of tumor-suppressive microRNAs (e.g., miR-584-5p, miR-29c-3p), thereby upregulating oncogenic targets (e.g., MAPK1, COL1A1/2)[2][5].\n- Recruitment of chromatin modifiers (EZH2, SUZ12, LSD1) to silence tumor suppressor genes (e.g., PLEKHO1, CDKN1A, KLF2, E-cadherin)[1][3][4].\n- Modulation of key cancer-related pathways, including MAPK/ERK, Wnt/β-catenin, and apoptosis control[2][6].\nDUXAP8 expression correlates with advanced tumor grade, poor prognosis, metastasis, and therapy resistance, making it a promising biomarker and a potential therapeutic target in oncology, especially for cancers such as gastric, colorectal, liver, lung, bladder, pancreatic, and renal cell carcinomas[1][2][3][4][5]. No direct small-molecule or antibody-based therapies currently target DUXAP8, but evidence suggests future therapeutic development potential.

Other names

DUXAP8Double homeobox A pseudogene 8 lncRNAlncRNA DUXAP8DUXAP8 lncRNA

Not a protein/receptor in classical sense, but as an RNA: Acts as a molecular sponge for microRNAs (e.g., miR-584-5p, miR-29c-3p) to regulate target mRNAs such as MAPK1, COL1A1, COL1A2[2][5]; Recruits chromatin modifiers (EZH2, SUZ12, LSD1) to epigenetically repress or activate gene targets[1][3][4]; Promotes chemoresistance by activating MAPK/ERK signaling pathway[2]