Target intelligence / Profile preview

Double-mutant Heat-labile Toxin Adjuvant (dmLT)

Target: dmLT
Molecular classification: Toxin derivative, Adjuvant, AB5 toxin

Overview

Double-mutant heat-labile toxin adjuvant (dmLT) is a rationally engineered protein derived from E. coli LT designed for safe use as a potent vaccine adjuvant. Its unique structure enables induction of broad immune responses—including robust IgA production—making it especially suitable for vaccines requiring strong protection at both systemic and mucosal surfaces.

Other names: LT(R192G/L211A)

Mechanism of action

Enhances APC activation; promotes mixed Th1/Th2/Th17 response via antigen uptake and cytokine production

Biological functions

Adjuvant activityImmune response enhancementAntigen uptake promotionDendritic cell activation

Disease associations

Vaccine developmentInfectious disease prevention

Safety considerations

Potential reactogenicity (less than native LT)Intranasal administration not recommended

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