Double plant homeodomain finger 2 (DPF2)

Double plant homeodomain finger 2 (DPF2) is a highly conserved transcription factor and chromatin regulator that contains a C2H2-type zinc finger domain and tandem plant homeodomain (PHD) finger motifs, enabling it to bind to and “read” specific acetylation and crotonylation marks on histones H3 and H4[1][2][3][4]. Through these interactions, DPF2 integrates into multi-protein complexes, notably the SWI/SNF chromatin remodeling complex, and modulates the transcription of target genes—often repressing myeloid differentiation by forming repressive complexes on specific promoters (such as miR-223) and regulating pathways such as non-canonical NF-κB signaling[1][2][3][4]. DPF2 is implicated in the pathogenesis of hematological malignancies (such as leukemia), development of lymphoid cells, and rare congenital syndromes like Coffin-Siris syndrome 7[1][3][4].

Other names

Zinc finger protein ubi-d4BAF45DREQUBID4SMARCG2Apoptosis response zinc finger proteinBRG1-associated factor 45DD4protein requiemCoffin-Siris syndrome 7 protein