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Target intelligence / Profile preview
Double-strand-break repair protein RAD21-like 1 (RAD21L1)
- Target
- RAD21L1
- Molecular classification
- Cohesin complex component, Structural chromosomal protein, α-kleisin family
01
Overview
RAD21L1 encodes a meiosis-specific cohesin complex subunit of the α-kleisin family, highly expressed in reproductive tissues such as testis and ovary[2][4]. The protein localizes to chromosome axes during the leptotene and zygotene stages of meiosis and is critical for synapsis and separation of homologous chromosomes[1][2][6]. In vertebrates such as zebrafish and mice, loss of RAD21L1 impairs oogenesis, causing defects in chromosome synapsis and triggering checkpoint-mediated cell death, leading to poor gamete quality and reduced fertility, while spermatogenesis is less affected[1]. RAD21L1 is essential for meiotic chromosome structure and integrity, but it is not currently a direct clinical or pharmacological target[1][6].
- Other names
- Double-strand-break repair protein rad21-like protein 1RAD21L1RAD21LdJ545L17.2RAD21-like 1
02
Biological functions
Meiotic chromosome segregationDouble-strand break repair during meiosisMaintenance of chromatid cohesionChromatin binding
03
Disease associations
Infertility (defects in oogenesis, impaired fertility, sex reversal in vertebrates)Aneuploidy (mis-segregation of chromosomes)Other (potential relevance to developmental abnormalities from chromosome missegration)
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