Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Double-stranded RNA-activated protein kinase (PKR)
- Target
- PKR
- Molecular classification
- Serine/threonine protein kinase, Pattern recognition receptor
01
Overview
Double-stranded RNA-activated protein kinase (PKR) is a serine/threonine protein kinase that plays a central role in the cellular response to viral infection and various stress signals. It is primarily known for its role in the innate immune response against viruses, becoming activated upon binding to double-stranded RNA (dsRNA). Once activated, PKR phosphorylates the eukaryotic translation initiation factor 2 alpha (eIF2α), leading to inhibition of global mRNA translation. Beyond antiviral defense, PKR also responds to other stressors and has regulatory functions balancing cell survival/apoptosis/inflammation.
02
Mechanism of action
Inhibition of eIF2α phosphorylation, inhibition of PKR dimerization and autophosphorylation, induction of apoptosis, modulation of inflammatory signaling pathways
03
Biological functions
Innate immune responseAntiviral defenseRegulation of mRNA translationApoptosis inductionInflammationCellular stress response
04
Disease associations
Viral infectionsAutoimmune disordersNeurodegenerative diseasesCancer
05
Safety considerations
Excessive or dysregulated activity may contribute to pathological inflammation/autoimmunity
Beyond the preview
Go deeper on Double-stranded RNA-activated protein kinase (PKR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Double-stranded RNA-activated protein kinase (PKR).