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Double-stranded RNA-dependent protein kinase (PKR)
- Target
- PKR
- Molecular classification
- eIF2α-kinase family, dsRNA-binding protein family, Serine/threonine kinase
01
Overview
Double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine kinase that plays a central role in the cellular response to various stress signals, particularly viral infection. It is activated primarily by double-stranded RNA (dsRNA), leading to autophosphorylation and activation of downstream signaling pathways, including inhibition of translation, induction of apoptosis, and activation of inflammatory responses. Dysregulation or excessive activation of PKR can contribute to various pathologies, including autoimmune disorders, neurodegenerative diseases, cancer, and metabolic disorders.
- Other names
- EIF2AK2
02
Mechanism of action
Inhibition of translation initiation via eIF2α phosphorylation, induction of apoptosis, activation of NF-kB
03
Biological functions
Antiviral defenseInflammatory signalingTumor suppressionCell differentiationRegulation of translation initiationInduction of apoptosisRegulation of autophagy
04
Disease associations
Autoimmune disordersNeurodegenerative diseasesCancer/tumorigenesisMetabolic disordersInflammationViral infection
05
Safety considerations
Overactivation implicated in autoimmune disordersDysregulation can contribute to pathology
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