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Doublecortin domain containing 1 (DCDC1)
- Target
- DCDC1
- Molecular classification
- Other, DCX superfamily member, Microtubule-associated protein
01
Overview
Doublecortin domain containing 1 (DCDC1) encodes a hydrophilic, intracellular protein that belongs to the doublecortin (DCX) superfamily. The protein contains a single doublecortin domain, which classifies it within the microtubule-associated protein family, though unlike other doublecortin family members (with tandem domains), DCDC1 does not bind microtubules or regulate their polymerization directly. Its canonical biological activity relates to mediating dynein-dependent vesicular transport, most notably the transport of RAB8A-positive vesicles during cytokinesis. DCDC1 expression is highest in adult testis and apparently also in the eye and embryonic brain. Currently, there are no drugs or therapies that directly target DCDC1, and it is not considered a canonical therapeutic target. Disease associations, such as oxidative phosphorylation deficiencies or COVID-19, are correlative rather than causative.
- Other names
- Doublecortin domain-containing protein 1DCDC1DCDC5KIAA1493FLJ46154Doublecortin domain-containing 5 protein
02
Mechanism of action
None applicable
03
Biological functions
Participates in dynein-dependent vesicle transport (especially RAB8A-positive vesicles to the midbody during cytokinesis)Does not bind microtubules or regulate microtubule polymerization
04
Disease associations
Combined oxidative phosphorylation deficiency 8Severe COVID-19 (association)
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