Doublecortin domain-containing protein 2 (DCDC2)

Doublecortin domain-containing protein 2 (DCDC2) is a microtubule-associated protein containing doublecortin domains, which bind to tubulin and enhance microtubule polymerization[1][2][3]. DCDC2 plays a critical role in *neuronal migration* and *cilia-related signaling* in developing neurons and sensory hair cells, influencing both cortical development and auditory function[1]. Mutations and regulatory variants in DCDC2 have been associated with *developmental dyslexia*, likely by affecting cilia-dependent processes in the brain that govern language and reading function[1][2][3]. Although linked to several rare diseases (including autosomal recessive deafness and neonatal sclerosing cholangitis), DCDC2 is best known for its role in neurodevelopment. There is no evidence that DCDC2 functions as a receptor, transporter, or enzyme, and it is not targeted by current pharmaceuticals[1][2][3].

Other names

DCDC2AKIAA1154RU2RU2SNPHP19DFNB66NSC

Not applicable—there are no drugs targeting DCDC2 directly