Down-regulator of transcription 1 (DR1)

Down-regulator of transcription 1 (DR1) is a TBP (TATA box-binding protein)-associated phosphoprotein that functions as a transcriptional repressor, affecting both basal and activated RNA polymerase II-dependent gene expression. DR1 contains a histone fold motif, TBP-binding domain, and a glutamine/alanine-rich region. It regulates transcription by binding TBP and forming a heterodimer with DRAP1, inhibiting assembly of the transcription preinitiation complex. Additionally, DR1 is a component of the ATAC complex, which has histone acetyltransferase activity. The protein influences chromatin organization and may open new directions for targeted drug discovery, though no established drugs directly interact with DR1 yet.

Other names

Down-regulator of transcription 1Protein Dr1DR1NC2-betaNegative cofactor 2-betaNegative cofactor 2NC2NC2BNCB2TATA-binding protein-associated phosphoproteinDR1LLOC100910207NC2-β1700121L09RikHGNC:3017UniProt Q01658Ensembl ENSG00000117505

Transcriptional repression via interaction with TATA-binding protein (TBP) and formation of repressor complexes (with DRAP1), which block assembly of preinitiation complexes and the association of other transcription factors (TFIIA/TFIIB) with TBP. Modulation of chromatin/histone acetylation status (via ATAC complex).