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Target intelligence / Profile preview
Downregulated RNA in cancer, inhibitor of cell invasion and migration (DRAIC)
- Target
- DRAIC
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Downregulated RNA in cancer, inhibitor of cell invasion and migration (DRAIC) is a long non-coding RNA (lncRNA) located on chromosome 15 and also known as PCAT29 or LINC00593. DRAIC is primarily studied in prostate cancer, where it was identified as a transcript downregulated in androgen-independent prostate cancer cells. DRAIC is thought to function as a tumor suppressor by inhibiting both cell invasion and migration, and reducing overall tumorigenic potential. Its expression is inversely associated with cancer progression, suggesting a beneficial, protective role. It belongs to the class of long intergenic non-coding RNAs and does not encode a protein product[1][4][5].
- Other names
- Downregulated RNA in androgen independent cellsProstate cancer associated transcript 29 (non-protein coding)PCAT29C15orf50LINC00593
02
Biological functions
Inhibition of cell invasionInhibition of cell migrationSuppression of tumorigenesis
03
Disease associations
Cancer (notably prostate cancer, but also associated with other malignancies such as melanoma and glioma as per related gene aliases)
04
Biomarkers
Potential biomarker for cancer diagnosis or prognosis, especially prostate cancer
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