dpy-19-like 3 pseudogene (XIAPP1)

The **dpy-19-like 3 pseudogene** (ENSG00000270333), also referred to as **E3 ubiquitin-protein ligase XIAP pseudogene** or **XIAPP1**, is a genomic DNA sequence classified as a pseudogene, meaning it is a non-functional remnant of a gene that has lost its protein-coding ability or is otherwise inactivated[^1^]. In this case, XIAPP1 resembles the gene for the **E3 ubiquitin-protein ligase XIAP (X-linked inhibitor of apoptosis protein)**, but it does not produce a functional protein. Pseudogenes may occasionally have regulatory functions but do not serve as direct drug targets, lack biological activity, and are not considered therapeutic targets in the sense used in pharmacology or drug development[1][5].\n\n[^1^]: [1][5]\n\nAdditional context: \n- ENSG00000270333 is explicitly annotated as a pseudogene in genomic resources, and there is no evidence it encodes an active protein product or functions as a molecular target.\n- The functional gene, **XIAP (BIRC4)**, is a different gene entirely and is an inhibitor of apoptosis protein, but it is not the pseudogene in question[1][4][5].\n- The presence of “E3 ubiquitin-protein ligase XIAP pseudogene, XIAPP1” as an alias highlights the homology, but also the lack of function, reinforcing that **this is not a drug target** and should not be confused with XIAP itself.\n\nSummary of errors: \n- The “dpy-19-like 3 pseudogene”/XIAPP1 is **not a target**; listing it as one is incorrect.\n\n--- \n\nIf you need information about the **functional XIAP protein (X-linked inhibitor of apoptosis protein / BIRC4)**, which is a validated drug target, refer specifically to those gene/protein entries instead[1][4][5].

Other names

E3 ubiquitin-protein ligase XIAP pseudogeneXIAP pseudogene 1XIAPP1ENSG00000270333dpy-19-like 3 pseudogene

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