Dpy-19 like C-mannosyltransferase 1 (DPY19L1)

Dpy-19 like C-mannosyltransferase 1 (DPY19L1) is a membrane-associated enzyme classified as a C-mannosyltransferase, which catalyzes the addition of mannose sugars specifically to tryptophan residues in target proteins that contain a WxxW or WxxC consensus motif[4][5][1]. This modification, known as C-mannosylation, is a unique form of protein glycosylation occurring in the endoplasmic reticulum where a mannose is transferred from dolichylphosphate mannose to the C2 atom of tryptophan[4][5][1]. DPY19L1 mainly targets the first two tryptophans in thrombospondin type-1 repeat (TSR) domains, which are present in several secreted and cell surface proteins involved in adhesion and signaling[1]. This enzymatic modification is important for the stability, folding, and secretion of these proteins, such as the netrin receptor UNC5A, supporting processes like protein trafficking from the endoplasmic reticulum to the plasma membrane[1][2][4]. Although DPY19 family members (particularly DPY19L2) have roles in human disease such as male infertility, the biological and disease relevance of DPY19L1 itself is less well understood, though some data suggest possible involvement in neurodevelopment and protein secretion disorders[5][2][1]. There are currently no known drugs targeting DPY19L1, and it is not established as a therapeutic target.

Other names

Protein C-mannosyl-transferase DPY19L1GA0500KIAA0877Dpy-19-like protein 1Protein dpy-19 homolog 1DPY-19-like protein 1Probable C-mannosyltransferase DPY19L1

Not applicable (no known direct pharmacological modulators or interacting drugs)