Target intelligence / Profile preview

DPYD intronic transcript 1 (DPYD-IT1)

Target: DPYD-IT1
Molecular classification: Other, non-coding RNA, long non-coding RNA

Overview

DPYD intronic transcript 1 (DPYD-IT1) is a non-coding RNA arising from the intronic sequence of the DPYD gene (which encodes dihydropyrimidine dehydrogenase, an enzyme associated with pyrimidine metabolism and relevant pharmacogenetic adverse drug reactions). DPYD-IT1 does not encode a functional protein, is not implicated as a drug target, and its individual biological or clinical significance is currently undefined. No direct molecular function or disease association is reported for DPYD-IT1 specifically; all major clinical and therapeutic implications pertain to mutations in the protein-coding DPYD gene itself.

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