Drug delivery via matrix-based encapsulation

Matrix-based encapsulation is a **drug delivery methodology** where active drugs (small molecules, proteins, biologics, or cells) are embedded within a matrix material such as (bio)polymers, hydrogels, liposomes, or other vehicles[1][2][4]. This approach provides a protective environment for the encapsulated agent, which can improve its stability, bioavailability, and control over its spatial and temporal release within the body[1][2][4]. Encapsulation is used to overcome challenges such as poor solubility, instability, toxicity, or rapid metabolism of certain drugs, and may help to minimize side effects by enabling controlled or targeted release at the desired site of action[1][4]. It is widely used in pharmaceuticals, nutraceuticals, and food technology, but it is *not* itself a therapeutic target such as a receptor, enzyme, or transporter. Instead, it is a formulation or engineering strategy applied to drugs[1][2][3][4]. Common encapsulation matrices include synthetic and natural polymers (e.g., PLGA, alginate), liposomes, and various hydrogel systems[2][4], with ongoing research focusing on improving control over drug release and minimizing potential immune responses[4].

Other names

Matrix-based drug deliveryEncapsulation (drug delivery)Matrix encapsulation