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Biological Target (General)
- Molecular classification
- Receptor, Enzyme, Ion Channel, G Protein-Coupled Receptor (GPCR), Kinase, Nuclear Hormone Receptor, Transporter, Nucleic Acid (DNA/RNA)
01
Overview
A biological target is any molecule within a living organism to which a drug or other molecule binds, resulting in a change in its function. Common classes of biological targets include proteins (enzymes, ion channels, receptors), nucleic acids (DNA/RNA), and other biomolecules. Drugs interact with targets through various mechanisms, including agonism, antagonism, and inhibition, leading to therapeutic effects or adverse reactions. Target identification and validation are crucial steps in drug discovery.
- Other names
- Drug TargetMolecular TargetTherapeutic Target
02
Mechanism of action
Agonism, Antagonism, Inhibition, Allosteric Modulation, Enzyme Inhibition, Receptor Activation/Blockade, Ion Channel Blockade/Modulation, Gene Expression Modulation
03
Biological functions
Signal transductionCatalysisIon transportGene expression regulationCellular metabolismNeurotransmissionImmune responseApoptosisCell proliferationCell differentiation
04
Disease associations
CancerInflammationNeurodegenerative diseaseCardiovascular diseaseInfectionMetabolic disordersAutoimmune diseasesGenetic disorders
05
Safety considerations
Off-target effectsDrug resistanceAdverse drug reactionsLimited efficacySpecies differences in target expression/functionTarget redundancyCompensatory mechanisms
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