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Target intelligence / Profile preview
DSN1 component of MIS12 kinetochore complex (DSN1)
- Target
- DSN1
- Molecular classification
- Other (Kinetochore complex protein), Structural protein
01
Overview
DSN1 is a structural subunit of the MIS12 kinetochore complex, a core component of the outer kinetochore. The MIS12 complex (MIS12C), which includes DSN1, NSL1, MIS12, and PMF1, acts as a critical bridge linking the inner centromere (CCAN via CENP-C) with the outer kinetochore microtubule-binding sites (NDC80 complex). DSN1 is essential for proper chromosome alignment and segregation during mitosis. Aurora B kinase regulates the MIS12 complex function by phosphorylating DSN1, facilitating kinetochore assembly and tension-sensitive error correction. Disruption of DSN1 impairs kinetochore formation, chromosome segregation, and cell division, leading to chromosomal instability—a hallmark of many cancers[1][2][3][5][6]. DSN1 is not a direct therapeutic target, receptor, or enzyme, but its role in mitosis makes it important for understanding mechanisms of chromosomal instability in disease contexts.
- Other names
- DSN1C20orf172KNL3MIS13dJ469A13.2hKNL-3DSN1 homologMIS12 kinetochore complex componentDSN1 component of MIS12 kinetochore complex
02
Biological functions
Chromosome segregationKinetochore assemblyCell cycle progressionRegulation of chromosome alignment during mitosis
03
Disease associations
Cancer (as a component essential for genomic stability, dysfunction can promote chromosomal instability in cancer)Other (“Hyperinsulinemic Hypoglycemia, Familial, 4” and “Peeling Skin Syndrome 4,” rare, possibly indirect associations)
04
Safety considerations
Loss or dysfunction can result in mitotic errors and chromosomal instability, relevant for disease and cancer biology
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