Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1)

Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1), also known as BAM32, is an adaptor protein expressed predominantly in B lymphocytes and other immune cells[1][2][4][6]. It contains an N-terminal Src homology 2 (SH2) domain and a C-terminal pleckstrin homology (PH) domain[4][5]. DAPP1 is rapidly recruited to the plasma membrane upon B cell receptor (BCR) engagement, where it is phosphorylated by Src-family kinases (such as Lyn) in a phosphatidylinositol 3-kinase (PI3K)-dependent manner[1][2][5]. DAPP1 serves as a scaffold that coordinates signaling complexes by binding 3-phosphoinositide lipids and interacting with proteins like phospholipase C gamma 2 (PLCγ2), promoting activation of pathways involved in cytoskeletal remodeling, receptor internalization, cell adhesion, and spreading[1][2][3][5][7]. It plays a critical role in BCR-mediated antigen presentation, efficient formation of immune synapses, and the generation of high-affinity antibody responses[1][3][7]. DAPP1 is also involved in regulating responses in neutrophils and dendritic cells and is required for reactive oxygen species production during inflammation[9]. There are no drugs or small molecules currently known to target DAPP1 directly.

Other names

Bam32B-cell adaptor molecule of 32 kDaB lymphocyte adaptor protein Bam32HSPC066hDAPP1