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Target intelligence / Profile preview
Dual Leucine Zipper Kinase (DLK)
- Target
- DLK
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAP3K, Mixed-Lineage Kinase (MLK)
01
Overview
Dual leucine zipper kinase (DLK), also known as MAP3K12, is a member of the mixed-lineage kinase (MLK) family and functions as a mitogen-activated protein kinase kinase kinase (MAPKKK). It is a serine/threonine protein kinase that regulates neuronal stress responses, axonal degeneration, and regeneration through downstream effectors like JNKs and p-c-Jun. DLK is a potential therapeutic target for preventing progressive neuronal loss in various neurological diseases.
- Other names
- MAP3K12Mixed-lineage kinase 12
02
Mechanism of action
Inhibition of DLK kinase activity to reduce neuronal degeneration
03
Biological functions
Signal transductionRegulation of neuronal degenerationRegulation of neuronal regenerationJNK pathway activationp38 pathway activationStress responseApoptosis
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)TauopathiesNeuropathic painTraumatic brain injury
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