Target intelligence / Profile preview

Dual Oxidase (DUOX)

Target: DUOX
Molecular classification: Enzyme, NOX/DUOX family, Oxidase

Overview

Dual oxidases (DUOX) are members of the NADPH oxidase (NOX) family of enzymes, characterized by their ability to generate reactive oxygen species (ROS), primarily hydrogen peroxide (H2O2). There are two main isoforms in humans: DUOX1 and DUOX2. These enzymes play essential roles in various physiological processes, including thyroid hormone biosynthesis, host defense mechanisms, and cellular signaling.

Mechanism of action

Inhibition of hydrogen peroxide production

Biological functions

Hydrogen peroxide productionThyroid hormone biosynthesisHost defenseRedox signalingRegulation of cell proliferation

Disease associations

Congenital hypothyroidismCystic fibrosis-related lung issuesCancerInflammation

Safety considerations

Excessive ROS productionAltered redox balance

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