Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 (MEK2)
- Target
- MEK2
- Molecular classification
- Enzyme, Protein Kinase, Dual-Specificity Kinase, MAP Kinase Kinase (MAPKK)
01
Overview
Dual specificity mitogen-activated protein kinase kinase 2 (MEK2), encoded by the MAP2K2 gene, is a key enzyme in the RAS/RAF/MEK/ERK signaling pathway. It phosphorylates and activates ERK1 and ERK2, which regulate cell growth, differentiation, and survival. MEK2 is implicated in cancer and developmental disorders like cardiofaciocutaneous syndrome. It is a therapeutic target for cancer treatment.
- Other names
- MKK2MAPKK 2PRKMK2ERK activator kinase 2MAPK/ERK kinase 2MAP2K2
02
Mechanism of action
MEK2 inhibitors block the phosphorylation and activation of ERK1/2, thereby inhibiting downstream signaling pathways involved in cell growth and survival.
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisCell migrationRegulation of ERK1/2 activity
04
Disease associations
CancerCardiofaciocutaneous syndromeDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to the involvement of the MAPK pathway in various cellular processes.Development of resistance to MEK inhibitors in cancer cells.
Beyond the preview
Go deeper on Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 (MEK2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 (MEK2).