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Dual specificity phosphatase 29 (DUSP29)
- Target
- DUSP29
- Molecular classification
- Enzyme, Protein tyrosine phosphatase, Dual specificity phosphatase (non-receptor class)
01
Overview
Dual specificity phosphatase 29 (DUSP29) is an atypical, non-receptor, dual specificity protein phosphatase able to dephosphorylate phosphotyrosine, phosphoserine, and phosphothreonine residues within the same substrate, with preference for phosphotyrosine. It modulates intracellular signaling cascades including attenuation of the ERK1/2 MAP kinase pathway and influences AMPK activity, especially in skeletal muscle, thereby impacting systemic glucose homeostasis, muscle cell differentiation, development, and neurogenic muscle atrophy. DUSP29 has also been linked to elevated glucocorticoid receptor signaling and is induced in conditions of skeletal muscle atrophy[1][2][3][6].
- Other names
- Dual specificity phosphatase and pro isomerase domain containing 1DUPD1Dual specificity phosphatase 27DUSP27FMDSP
02
Mechanism of action
Dephosphorylation of phosphotyrosine, phosphoserine, and phosphothreonine residues within substrates (preference for phosphotyrosine)
03
Biological functions
Protein dephosphorylationRegulation of MAP kinase signaling (ERK1/2 branch)Modulation of AMPK activityMuscle cell differentiationRegulation of glucose homeostasis
04
Disease associations
Muscular atrophyAbdominal obesity-metabolic syndromeVariola major (reported in gene-disease associations)
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