Dual specificity phosphatase 5 pseudogene 1 (DUSP5P1)

Dual specificity phosphatase 5 pseudogene 1 (DUSP5P1) is a human pseudogene and long non-coding RNA, previously annotated as FLJ34941 and DUSP5P, without protein-coding function. While DUSP5P1 lacks enzymatic/catalytic activity, its transcript is overexpressed in certain cancers—such as Hodgkin lymphoma, acute myeloid leukemia, and gastric cancer. DUSP5P1 modulates tumor cell biology by transcriptionally regulating genes involved in cell migration, invasion, and apoptosis, principally by direct regulation of genes like ARHGAP5 and influencing MAPK signaling pathways. High DUSP5P1 expression is associated with increased metastasis, drug resistance, and poor prognosis in gastric cancer patients. It is not considered a classic therapeutic target such as a receptor, enzyme, or transporter, and is instead studied as a cancer biomarker and a potential regulatory RNA involved in tumorigenesis.

Other names

DUSP5PFLJ34941

Not directly applicable as a target Indirect: Modulates transcription of genes such as ARHGAP5, impacting focal adhesion and MAPK signaling; influences cell migration, invasion, and drug resistance