Dual specificity protein phosphatase 10 (DUSP10)

Dual specificity protein phosphatase 10 (DUSP10) is a cytoplasmic and nuclear enzyme that dephosphorylates both phosphoserine/threonine and phosphotyrosine residues on its substrates, especially members of the MAPK family such as p38 and JNK but not ERK[1][2][6]. By inactivating MAPKs, DUSP10 negatively regulates cellular processes including proliferation, differentiation, and the response to stress and inflammation[1][2][6]. DUSP10 is widely expressed, inducible by external stress stimuli, and its dysregulation has been associated with diseases such as cancer and inflammation[2].

Other names

Mitogen-activated protein kinase phosphatase 5MKP-5MKP5Dual specificity phosphatase MKP-5MAP kinase phosphatase 5Dual specificity phosphatase 10

Dephosphorylation (inactivation) of p38 MAPKs and JNK (c-Jun N-terminal kinases); drugs would likely act by modulating protein phosphatase activity