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Target intelligence / Profile preview
Dual specificity protein phosphatase 13A (DUSP13A)
- Target
- DUSP13A
- Molecular classification
- Enzyme, Protein tyrosine phosphatase, Dual specificity phosphatase
01
Overview
Dual specificity protein phosphatase 13A (DUSP13A) is an enzyme of the protein tyrosine phosphatase superfamily that acts on both phosphotyrosine and phosphoserine/threonine residues. It is expressed primarily in skeletal muscle and has regulatory roles in apoptosis signaling (notably MAP3K5/ASK1-mediated pathways). DUSP13A is considered a druggable target due to its allosteric sites as revealed by structural studies, with potential roles in cell growth, differentiation, and disease states including certain cancers and metabolic disorders
- Other names
- Dual specificity phosphatase 13ADUSP13BEDPMDSPSKRP4TMDPmuscle-restricted dual specificity phosphatasebranching-enzyme interacting DSPDUSP13Bdual specificity phosphatase 13
02
Mechanism of action
Drugs targeting DUSP13A would likely act as allosteric modulators or inhibitors of phosphatase activity
03
Biological functions
Dephosphorylation (phosphotyrosine and phosphoserine/threonine residues)Cell proliferationCell differentiationRegulation of MAP3K5/ASK1-mediated apoptosis
04
Disease associations
CancerDiabetesDepressionOther (general roles in cell growth and differentiation relevant to multiple diseases)
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