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Target intelligence / Profile preview
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
- Target
- DYRK1A
- Molecular classification
- Enzyme, Protein Kinase, CMGC Kinase, DYRK Kinase
01
Overview
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is a serine/threonine kinase involved in regulating multiple cellular processes, including cell proliferation, DNA damage repair, neuronal development, and apoptosis. Its overexpression in Down syndrome contributes to cognitive deficits, and mutations are linked to autism spectrum disorder and mental retardation. While it acts as oncogene or tumor suppressor in cancer, DYRK1A selective inhibitors are under investigation as potential therapeutics across numerous diseases.
02
Mechanism of action
DYRK1A inhibitors (various mechanisms)
03
Biological functions
Cell cycle regulationDNA damage repairTranscriptional regulationApoptosis controlSynaptic functionNeuronal developmentUbiquitination
04
Disease associations
Down syndromeAutism spectrum disorderMental RetardationHIV/AIDSCancerNeurodevelopmental Disorders
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesContext-dependent role in cancer complicates therapeutic targeting
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