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Target intelligence / Profile preview
Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B)
- Target
- DYRK1B
- Molecular classification
- Protein kinase, Dual-specificity kinase, Serine/threonine/tyrosine kinase
01
Overview
DYRK1B is a dual-specificity kinase belonging to the DYRK family. It plays a role in cell cycle regulation, promoting G0/G1 transition and growth arrest. It is involved in DNA repair, specifically ribosomal DNA double-strand break repair. DYRK1B is crucial for myoblast differentiation into skeletal muscle cells and adipogenesis. Overexpression or dysregulation has been implicated in cancer cell survival and metabolic syndrome-related diseases.
- Other names
- MIRKAOMS3minibrain-related kinase
02
Mechanism of action
DYRK1B inhibitors
03
Biological functions
Cell cycle regulationDNA repairMyoblast differentiationAdipogenesisTranscription coactivator activityCell survival
04
Disease associations
CancerMetabolic syndromeCardiovascular disease
05
Safety considerations
Potential for off-target effects due to kinase family homology
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