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Target intelligence / Profile preview
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
- Target
- DYRK2
- Molecular classification
- Enzyme, Serine/threonine-protein kinase, Dual-specificity kinase
01
Overview
DYRK2 is a dual-specificity kinase involved in regulating several key cellular processes, including cell cycle, apoptosis, and protein synthesis. It functions as a scaffold for E3 ubiquitin ligase complexes and phosphorylates substrates like 4E-BP1 and STIM1. DYRK2 is implicated in cancer biology and is being explored as a therapeutic target in oncology.
02
Mechanism of action
DYRK2 kinase inhibition leading to modulation of downstream signaling pathways (e.g., p53-dependent apoptosis, 4E-BP1 phosphorylation, STIM1 phosphorylation)
03
Biological functions
Cell cycle regulationApoptosisCell proliferationCytoskeleton organizationProtein synthesis regulationCalcium signaling
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Potential for off-target effects due to kinase family similarityUnintended consequences of disrupting fundamental cellular processes like cell cycle and apoptosis
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