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Target intelligence / Profile preview
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)
- Target
- DYRK3
- Molecular classification
- Enzyme, Protein Kinase, Dual-Specificity Kinase, DYRK family
01
Overview
DYRK3 is a dual-specificity protein kinase involved in various cellular processes, including organelle dynamics during mitosis and regulation of erythropoiesis. It autophosphorylates on both serine/threonine and tyrosine residues and can phosphorylate histones. Its kinase activity is crucial for the disassembly of membraneless organelles during mitosis. DYRK3 also plays a role in erythroid cell development by modulating cell survival and inhibiting apoptosis. It has potential involvement in cAMP/PKA signaling pathways.
- Other names
- REDKRegulatory erythroid kinaseDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
AutophosphorylationProtein phosphorylationRegulation of erythropoiesisRegulation of apoptosisOrganelle disassembly during mitosisStress granule modulationcAMP/PKA signaling
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