Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase Family (DYRK)
- Target
- DYRK
- Molecular classification
- Protein kinase, Enzyme, DYRK family
01
Overview
The DYRK family comprises a group of protein kinases known for their ability to phosphorylate both serine/threonine and tyrosine residues. This dual specificity is unique. The family is evolutionarily conserved and involved in various cellular processes, including cell proliferation, development, DNA damage response, and gene expression. DYRK genes have notable clinical relevance, with DYRK1A implicated in Down syndrome and autism spectrum disorder. Inhibitors targeting one or more family members are being explored therapeutically for diseases where increased kinase activity contributes to pathology.
02
Mechanism of action
Kinase inhibition
03
Biological functions
Cell proliferationDevelopmental processesNeurogenesisDNA damage responseDouble-strand break repairGene expression regulationCell cycle regulation
04
Disease associations
Down syndromeAutism spectrum disorderHIV progressionCancerNeurodevelopmental disorders
05
Interacting drugs
D06MBI
1 more in the full profile.
Beyond the preview
Go deeper on Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase Family (DYRK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase Family (DYRK).