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Target intelligence / Profile preview
Duplex DNA Major Groove
- Molecular classification
- Nucleic Acid Structure, DNA Structural Feature
01
Overview
The major groove of duplex DNA is a structural feature formed by the helical arrangement of the two DNA strands. It is a wider groove compared to the minor groove and exposes the edges of nucleotide bases, making them accessible for interactions with proteins, drugs, and other molecules. It plays a critical role in DNA-protein interactions, transcription regulation, DNA replication, and DNA repair. The major groove is a therapeutic target for drug design, gene regulation, and modulation of DNA structure.
- Other names
- DNA Major GrooveMajor GrooveMajor Groove of DNA
02
Mechanism of action
Modulation of DNA-protein interactions; direct DNA binding
03
Biological functions
DNA-protein interactionTranscription regulationDNA replicationDNA repairDrug binding
04
Disease associations
CancerGenetic DiseasesInfection
05
Safety considerations
Off-target bindingNon-specific interactionsPotential for genomic instability
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