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dUTP pyrophosphatase (dUTPase)
- Target
- dUTPase
- Molecular classification
- Enzyme
01
Overview
dUTP pyrophosphatase (dUTPase) is an essential enzyme that catalyzes the hydrolysis of dUTP to dUMP and PPi, preventing uracil incorporation into DNA and providing dUMP for thymidine nucleotide production. It plays a critical role in maintaining genome integrity and is a potential target for chemotherapeutic drug design.
- Other names
- deoxyuridine-triphosphatasedesoxyuridine 5'-triphosphate nucleotidohydrolasedesoxyuridine 5'-triphosphatasedUTP nucleotidohydrolase
02
Mechanism of action
Inhibition of dUTP pyrophosphatase leads to increased uracil incorporation into DNA and cell death, thus preventing cancer cell proliferation.
03
Biological functions
Nucleotide metabolismDNA repairThymidylate biosynthesisGenome integrity
04
Disease associations
Cancer
05
Safety considerations
Loss or inhibition leads to lethal genomic instability
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